Assoc. Prof. Dr. Osman Metin İpcioğlu

Mezuniyet GATA Askeri Tıp Fakültesi, Etlik, Ankara

GATA Haydarpaşa Eğitim Hastanesi, Biyokimya ve Klinik Biyokimya Servisi, Üsküdar, İSTANBUL

Histoloji ve Embriyoloji Bölümü; Fırat Üniversitesi, ELAZIĞ

Transgenik PAI-1 Mutasyon Projesi FCVRI, Northwestern Üniversitesi, Chicago, ABD.

Klinik biyokimya

Ölçüm yöntemleri optimizasyonu

Moleküler genetik

Moleküler tanı yöntemleri

Tek karbon metabolizması

Metabolizmanın integrasyonu

Dirençli demir eksikliği anemisi

Transgenik modifikasyon teknikleri

Biyokimya Uzmanı; Ersoy Hastanesi, İstanbul

Biyokimya Uzmanı; Türkan Saylan Tıp Merkezi, İstanbul

Visiting Scholar; FCVRI, Northwestern Üniversitesi, Chicago, ABD

Doçent; GATA Haydarpaşa Eğitim Hastanesi Tıbbi Biyokimya Servisi, İstanbul

Yardımcı Doçent; GATA Haydarpaşa Eğitim Hastanesi Tıbbi Biyokimya Servisi, İstanbul

Biyokimya Uzmanı; Elazığ Asker Hastanesi, Elazığ (tam zamanlı)

Biyokimya Uzmanı; Özel Ufuk Tıp Merkezi ve Doğumevi (yarı zamanlı), Elazığ

Acil Hekimi; Türk Görev Kuvvet Komutanlığı Hastanesi, Zenica, Bosna Hersek

Pratisyen Hekim ; 4. Mekanize P.Tugayı 30 Yataklı Seyyar Cerrahi Hastanesi Baştabibi, Keşan, Edirne

İntern; GATA, Gülhane Tıp Fakültesi, Ankara

Deneysel Araştırma Kursu-Erciyes Üniversitesi Hakan Çetinsaya Deneysel ve Klinik Araştırma Merkezi, Kayseri

Deneysel Araştırma Kursu-GATA , Ankara

Deney Araştırma Kullanım Kursu-GATA Haydarpaşa Deneysel Araştırma ve Uygulama Laboratuvarı, İstanbul

Folate and homocysteine metabolisms and their roles in the biochemical basis of neuropsychiatry.Coşar A, Ipçioğlu OM, Ozcan O, Gültepe M.Turk J Med Sci. 2014;44(1):1-9. Review.

Comparison of 4 % icodextrin and omega 3 Fatty acids in prevention of peritoneal adhesions.Karakas DO, Yigitler C, Gulec B, Kucukodaci Z, Ipcioglu OM, Akin ML.Indian J Surg. 2014 Jun;76(3):181-6.

Trimetazidine significantly reduces cerulein-induced pancreatic apoptosis. Tanoglu A, Yazgan Y, Kaplan M, Berber U, Kara M, Demırel D, Ipcioglu OM. Clin Res Hepatol Gastroenterol. 2014 Jul 4. pii: S2210-7401(14)00148-X.

Effectiveness of interleukin-1 receptor antagonist (Anakinra) on cerulein-induced experimental acute pancreatitis in rats.Kaplan M, Yazgan Y, Tanoglu A, Berber U, Oncu K, Kara M, Demirel D, Kucuk I, Ozari HO, Ipcioglu OM.Scand J Gastroenterol. 2014 Sep;49(9):1124-30.

Evaluation of MMP-9 and TIMP-1 Levels of the Patients with Nasal Polyposis After Corticosteroid Therapies. Cincik H, Erkul E, Pinar D, Ipcioglu O, Gungor A, Cekin E, Cakmak A.Indian J Otolaryngol Head Neck Surg. 2013 Aug;65(Suppl 2):445-9.

Comparison of the effects of first and second generation silicone hydrogel contact lens wear on tear film osmolarity. Iskeleli G, Karakoc Y, Ozkok A, Arici C, Ozcan O, Ipcioglu O. Int J Ophthalmol. 2013 Oct 18;6(5):666-70.

Comparison of deferoxamine and methylprednisolone: protective effect of pharmacological agents on lipid peroxidation in spinal cord injury in rats. Dinc C, Iplikcioglu AC, Atabey C, Eroglu A, Topuz K, Ipcioglu O, Demirel D. Spine (Phila Pa 1976). 2013 Dec 15;38(26):E1649-55.

Can serum fetuin-A be regarded as an inflammatory marker among patients with familial Mediterranean fever? Oncu K, Yazgan Y, Tanoglu A, Kaplan M, Ermis F, Ipcioglu OM, Kara M, Kucuk I, Ozari HO.Dig Dis Sci. 2013 Nov;58(11):3212-7.

Detection of functional vitamin B12 and folate deficiencies, while serum levels are normal.Cosar A, Ipcioglu OM.Blood Transfus. 2014 Jan;12 Suppl 1:s164. doi: 10.2450/2013.0040-13. Epub 2013 Apr 17.

Low folate and vitamin B12 nourishment is common in Omani children with newly diagnosed autism.Cosar A, Ipcioglu OM.Nutrition. 2013 Sep;29(9):1170.

Elderly women: homocysteine reduction by short-term folic acid supplementation resulting in increased glucose concentrations and affecting lipid metabolism (C677T MTHFR polymorphism).Cosar A, Ipcioglu OM.Nutrition. 2013 Sep;29(9):1171.

Adiponectin and visfatin levels in extremely low birth weight infants; they are also at risk for insulin resistance.Cekmez F, Canpolat FE, Pirgon O, Aydemir G, Tanju IA, Genc FA, Tunc T, Aydinöz S, Yildirim S, Ipcioglu OM, Sarici SU.Eur Rev Med Pharmacol Sci. 2013 Feb;17(4):501-6.

Effects of levobupivacaine on wound healing.Zeren S, Kesici S, Kesici U, Isbilir S, Turkmen UA, Ulusoy H, Karpuz V, Ozcan O, Polat E, Ipcioglu OM, Sari MK.Anesth Analg. 2013 Feb;116(2):495-9.

Prolidase enzyme activity in varicose venous walls related to sperm count in patients with varicocele.Ozcan O, Malkoc E, Cosar A, Ipcioglu OM, Gultepe M, Muftuoglu T, Hira S, Ates F.Scand J Clin Lab Invest. 2013 Mar;73(2):97-101.

Effects of hemoperitoneum on wound healing and fibrinolytic activity in colonic anastomosis.Köksal N, Uzun MA, Ozkan OF, Kayahan M, Ipçioğlu OM, Günerhan Y, Ergün E, Güneş P.Ulus Travma Acil Cerrahi Derg. 2012 Jul;18(4):283-8.

High Frequency of Inherited Variants in the MEFV Gene in Acute Lymphocytic Leukemia.Sayan O, Kilicaslan E, Celik S, Tangi F, Erikci AA, Ipcioglu O, Sanisoglu YS, Nalbant S, Oktenli C.Indian J Hematol Blood Transfus. 2011 Sep;27(3):164-8.

Unexpectedly low asymmetric dimethylarginine (ADMA) and homocysteine levels in patients with phenylketonuria(PKU).Ozcan O, Ipcioglu OM, Gultepe M.J Inherit Metab Dis. 2012 Nov;35(6):1153

Are increased carotid artery pulsatility and resistance indexes early signs of vascular abnormalities in young obese males?Ozari HO, Oktenli C, Celik S, Tangi F, Ipcioglu O, Terekeci HM, Top C, Uzun M, Sanisoglu YS, Nalbant S.J Clin Ultrasound. 2012 Jul-Aug;40(6):335-40.

Effects of alpha tocopherol and ascorbic acid on Helicobacter pylori colonization and the severity of gastric inflammation.Sezikli M, Çetinkaya ZA, Güzelbulut F, Çimen B, Özcan Ö, Özkara S, Yeşil A, Gümrükçü G, Ipçioğlu OM, Sezikli H, Ovünç AO.Helicobacter. 2012 Apr;17(2):127-32.

Frequency of inherited variants in the MEFV gene in myelodysplastic syndrome and acute myeloid leukemia.Celik S, Oktenli C, Kilicaslan E, Tangi F, Sayan O, Ozari HO, Ipcioglu O, Sanisoglu YS, Terekeci MH, Erikci AA.Int J Hematol. 2012 Mar;95(3):285-90.

Apelin, vaspin, visfatin and adiponectin in large for gestational age infants with insulin resistance. Cekmez F, Canpolat FE, Pirgon O, Çetinkaya M, Aydinoz S, Suleymanoglu S, Ipcioglu OM, Sarici SU.Cytokine. 2011 Nov;56(2):387-91.

New adipocytokines (vaspin, apelin, visfatin, adiponectin) levels in children treated with valproic acid.Meral C, Cekmez F, Vurucu S, Tascılar E, Pirgon O, Canpolat FE, Ipcioglu OM, Aydemir G, Aydınoz S.Eur Cytokine Netw. 2011 Jun;22(2):118-22.

Can procalcitonin predict bone infection in people with diabetes with infected foot ulcers? A pilot study.Mutluoğlu M, Uzun G, İpcioğlu OM, Sildiroglu O, Özcan Ö, Turhan V, Mutlu H, Yildiz S.Diabetes Res Clin Pract. 2011 Oct;94(1):53-6.

Diagnostic value of resistin and visfatin, in comparison with C-reactive protein, procalcitonin and interleukin-6 in neonatal sepsis.Cekmez F, Canpolat FE, Cetinkaya M, Aydinöz S, Aydemir G, Karademir F, Ipcioglu OM, Sarici SÜ.Eur Cytokine Netw. 2011 Jun;22(2):113-7.

IGF-I and visfatin levels in retinopathy of prematurity.Cekmez F, Canpolat FE, Çetinkaya M, Pirgon O, Aydinoz S, Ceylan OM, Ipcioglu OM, Sarici SU.J Pediatr Ophthalmol Strabismus. 2012 Mar-Apr;49(2):120-4.

Increased iron and oxidative stress are separately related to cognitive decline in elderly.Umur EE, Oktenli C, Celik S, Tangi F, Sayan O, Sanisoglu YS, Ipcioglu O, Terekeci HM, Top C, Nalbant S, Kucukardali Y.Geriatr Gerontol Int. 2011 Oct;11(4):504-9.

Hydroxyproline levels in nasal polyps.Cincik H, Kapucu B, Ipcioglu OM, Gungor A, Dursun E.Eur Arch Otorhinolaryngol. 2011 Aug;268(8):1147-50.

Effect of hyperbaric oxygen therapy on bone prefabrication in rats.Sever C, Uygur F, Külahçı Y, Torun Köse G, Urhan M, Küçükodacı Z, Uzun G, Ipçioğlu O, Caycı T.Acta Orthop Traumatol Turc. 2010;44(5):403-9.

Combined hyperbaric oxygen and hypothermia treatment on oxidative stress parameters after spinal cord injury: an experimental study.Topuz K, Colak A, Cemil B, Kutlay M, Demircan MN, Simsek H, Ipcioglu O, Kucukodaci Z, Uzun G.Arch Med Res. 2010 Oct;41(7):506-12.

Association between symptom improvement and change of body mass index, lipid profile, and leptin, ghrelin, and cholecystokinin levels during 6-week olanzapine treatment in patients with first-episode psychosis.Basoglu C, Oner O, Ates AM, Algul A, Semiz UB, Ebrinc S, Cetin M, Ozcan O, Ipcioglu OM.J Clin Psychopharmacol. 2010 Oct;30(5):636-8.

Renal zinc clearance/glomerular filtration rate ratio as an indicator of marginal zinc deficiency associated with iron deficiency in childhood.Tural E, Meral C, Suleymanoglu S, Karademir F, Aydinoz S, Ozkaya H, Gültepe M, Ipcioglu OM, Gocmen I.J Am Coll Nutr. 2010 Apr;29(2):107-12.

Elevated plasma levels of apelin in children with type 1 diabetes mellitus.Meral C, Tascilar E, Karademir F, Tanju IA, Cekmez F, Ipcioglu OM, Ercin CN, Gocmen I, Dogru T.J Pediatr Endocrinol Metab. 2010 May;23(5):497-502.

Curcumin improves early functional results after experimental spinal cord injury.Cemil B, Topuz K, Demircan MN, Kurt G, Tun K, Kutlay M, Ipcioglu O, Kucukodaci Z.Acta Neurochir (Wien). 2010 Sep;152(9):1583-90; discussion 1590.

Plasma orexin A, ghrelin, cholecystokinin, visfatin, leptin and agouti-related protein levels during 6-week olanzapine treatment in first-episode male patients with psychosis.Basoglu C, Oner O, Gunes C, Semiz UB, Ates AM, Algul A, Ebrinc S, Cetin M, Ozcan O, Ipcioglu O.Int Clin Psychopharmacol. 2010 May;25(3):165-71.

Dilatation of the ascending aorta is associated with low serum prolidase activity.Akcakoyun M, Pala S, Esen O, Acar G, Kargin R, Emiroglu Y, Tigen K, Ozcan O, Ipcioglu OM, Esen AM.Tohoku J Exp Med. 2010 Apr;220(4):273-7.

The relationship between coronary calcification and the metabolic markers of osteopontin, fetuin-A, and visfatin.Uz O, Kardeşoğlu E, Yiğiner O, Baş S, Ipçioğlu OM, Ozmen N, Aparci M, Cingözbay BY, Işilak Z, Cebeci BS.Turk Kardiyol Dern Ars. 2009 Sep;37(6):397-402.

Covering the colon anastomoses with amniotic membrane prevents the negative effects of early intraperitoneal 5-FU administration on anastomotic healing.Uludag M, Ozdilli K, Citgez B, Yetkin G, Ipcioglu OM, Ozcan O, Polat N, Kartal A, Torun P, Isgor A.Int J Colorectal Dis. 2010 Feb;25(2):223-32.

Cord plasma concentrations of visfatin, adiponectin and insulin in healthy term neonates: positive correlation with birthweight.Cekmez F, Pirgon O, Tanju A, Ipcioglu OM.Int J Biomed Sci. 2009 Sep;5(3):257-60.

Sacroiliitis and muscle cramps in a healthy young man: some spearhead on MTHFR mutations. Gültepe M, Ozcan O, Ipçioğlu OM, Kiralp MZ, Ozçakar L.Rheumatol Int. 2010 May;30(7):995-6.

Perinatal risk factors affecting the maternal and fetal asymmetric dimethylarginine levels.Kul M, Demirkaya E, Ipçioğlu OM, Karadeniz RS, Tunç T, Vurucu S, Yeşil FG, Oztin H, Cakir E.Turk J Pediatr. 2009 Mar-Apr;51(2):141-5.

The association of oxidative stress and nasal polyposis.Cekin E, Ipcioglu OM, Erkul BE, Kapucu B, Ozcan O, Cincik H, Gungor A.J Int Med Res. 2009 Mar-Apr;37(2):325-30.

Plasma apelin and asymmetric dimethylarginine levels in type 2 diabetic patients with diabetic retinopathy.Yonem A, Duran C, Unal M, Ipcioglu OM, Ozcan O.Diabetes Res Clin Pract. 2009 Jun;84(3):219-23.

The comparison of the effects of different doses of levobupivacaine infiltration on wound healing.Dere K, Sen H, Teksoz E, Ozkan S, Dagli G, Sucullu I, Filiz AI, Ipcioglu OM, Kucukodaci Z.J Invest Surg. 2009 Mar-Apr;22(2):112-6.

Posttreatment with aminoguanidine attenuates renal ischemia/reperfusion injury in rats.Onem Y, Ipcioglu OM, Haholu A, Sen H, Aydinoz S, Suleymanoglu S, Bilgi O, Akyol I.Ren Fail. 2009;31(1):50-3.

Plasma osteoprotegerin concentrations in type 2 diabetic patients and its association with neuropathy.Terekeci HM, Senol MG, Top C, Sahan B, Celik S, Sayan O, Kucukardali Y, Ipcioglu O, Cagiltay E, Oktenli C, Ozata M.Exp Clin Endocrinol Diabetes. 2009 Mar;117(3):119-23.

Diagnostic value of serum prolidase enzyme activity to predict the liver histological lesions in non-alcoholic fatty liver disease: a surrogate marker to distinguish steatohepatitis from simple steatosis.Kayadibi H, Gültepe M, Yasar B, Ince AT, Ozcan O, Ipcioglu OM, Kurdas OO, Bolat B, Benek YZ, Guveli H, Atalay S, Ozkara S, Keskin O.Dig Dis Sci. 2009 Aug;54(8):1764-71.

N-terminal pro-B-type natriuretic peptide levels increases after hyperbaric oxygen therapy in diabetic patients.Yildiz S, Uzun G, Uz O, Ipcioglu OM, Kardesoglu E, Ozcan O.Clin Invest Med. 2008 Oct 1;31(5):E231-5.

Plasma ghrelin levels in males with idiopathic hypogonadotropic hypogonadism.Duran C, Yonem A, Ustun I, Ozcan O, Ipcioglu OM, Basekim CC.Endocrine. 2008 Aug-Dec;34(1-3):81-6.

Second trimester amniotic fluid annexin A5 levels and subsequent development of intrauterine growth restriction.Dundar O, Yoruk P, Tutuncu L, Muhcu M, Ipcioglu O, Ergur AR, Mungen E.Prenat Diagn. 2008 Oct;28(10):887-91.

Analyses of subjects with hypokalemic metabolic alkolosis, Gitelman's and Bartter's syndrome.Onem Y, Kucukardali Y, Sahan B, Atasoyu EM, Ipcioğlu O, Terekeci H, Solmazgul E, Top C, Oktenli C.Ren Fail. 2008;30(7):691-4.

Reduced urinary excretion of homocysteine could be the reason of elevated plasma homocysteine in patients with psychiatric illnesses.Ipcioglu OM, Ozcan O, Gultepe M, Ates A, Basoglu C, Cakir E.Clin Biochem. 2008 Jul;41(10-11):831-5.

Novel links between the long pentraxin 3, endothelial dysfunction, and albuminuria in early and advanced chronic kidney disease.Suliman ME, Yilmaz MI, Carrero JJ, Qureshi AR, Saglam M, Ipcioglu OM, Yenicesu M, Tong M, Heimbürger O, Barany P, Alvestrand A, Lindholm B, Stenvinkel P.Clin J Am Soc Nephrol. 2008 Jul;3(4):976-85.

Prolidase activity in serum and pleural fluids in patients with tuberculous pleural effusion [correction of effussion].Ipcioglu OM, Ozcan O, Gultepe M, Deniz O, Akgul EO.Clin Biochem. 2008 Jun;41(9):670-5.

First trimester screening for Down syndrome in rhesus negative women.Muhcu M, Mungen E, Atay V, Ipcioglu OM, Dundar O, Ergur R, Yergok YZ.Prenat Diagn. 2008 May;28(5):404-7.

Altered red cell membrane compositions related to functional vitamin B(12) deficiency manifested by elevated urine methylmalonic acid concentrations in patients with schizophrenia.Ozcan O, Ipçioğlu OM, Gültepe M, Başoğglu C.Ann Clin Biochem. 2008 Jan;45(Pt 1):44-9.

Hyperbaric oxygen treatment augments the efficacy of cilazapril and simvastatin regimens in an experimental nephrotic syndrome model.Sonmez A, Yilmaz MI, Korkmaz A, Topal T, Caglar K, Kaya A, Eyileten T, Yenicesu M, Oguz Y, Basal S, Ipcioglu OM, Vural A.Clin Exp Nephrol. 2008 Apr;12(2):110-8.

Assessment of iodine intake in mildly iodine-deficient pregnant women by a new automated kinetic urinary iodine determination method.Gültepe M, Ozcan O, Ipçioglu OM.Clin Chem Lab Med. 2005;43(3):280-4.

Gebelerdeki serbest radikal düzeyine; demir alımının, fonksiyonel vitamin B12 eksikliğinin ve ALA düzeylerinin etkisinin incelenmesi.