Assoc. Prof. Dr. Doğaç Okşen

2015 — Стамбульский университет, медицинский факультет Джеррахпаша, диплом врача

2020 — Стамбульский университет–Джеррахпаша, Институт кардиологии, ординатура по кардиологии

Коронарография

Стентирование и сложные коронарные вмешательства

Внутрисосудистое УЗИ (IVUS), заболевания периферических сосудов и интервенционное лечение

Имплантация кардиостимулятора

Пороки клапанов сердца и нехирургическое лечение

Профилактическая кардиология

2015–2016 — Kars Harakani State Hospital — Отделение неотложной помощи

2016–2020 — Istanbul University Cerrahpaşa, Institute of Cardiology — Научный сотрудник и ординатор

2020–2021 — Siirt Kurtalan State Hospital — Кардиолог

2020–2021 — Siirt Training and Research Hospital — Кардиолог

Турецкое кардиологическое общество

Европейское общество кардиологов (ESC)

Электронный курс надлежащей клинической практики — 14.06.2016

Yusuf İnci, Hasan Ali Barman, Doğaç Okşen, Ömer Doğan, Abdullah Ömer Ebeoğlu, Sercan Çayırlı, Mehmet Rasih Sonsöz, Mehmet Nail Bilen, Sait Mesut Doğan. Comparison of Bleeding Risk Scores in Atrial Fibrillation Patients on Direct-Acting Oral Anticoagulants: A Real-Life Study. Koşuyolu Heart Journal. 2026. DOI: 10.51645/khj.2026.600

Çağdaş Kaynak, Muzaffer Aslan, Ayfer Ertekin, Dogac Oksen, Necip Nas. Atherogenic Lipid Profiles and Cardiovascular Risk Indices in Epilepsy: A Retrospective Study. Sakarya Medical Journal. 2026. DOI: 10.31832/smj.1751489

Dogac Oksen, Muhammed H. Gecit, Zubeyir Bulat, Mehmet E. Gokce, Mehmet E. Bilgin, Sahra Balcioglu, Sukru Arslan, Veysel Oktay. Comparative prognostic performance of the FIB-4 index versus SYNTAX and GRACE scores in predicting major cardiovascular events in acute coronary syndrome. Advances in Interventional Cardiology. 2025. DOI: 10.5114/aic.2025.153923

Dogac Oksen, Sukru Arslan, Muhammed Heja Gecit, Esra Erturk Tekin, Veysel Oktay, Okay Abaci. Naples Prognostic Score Predicts New-Onset Atrial Fibrillation in Patients with ST-Elevated Myocardial Infarction Undergoing Primary Angioplasty. Arquivos Brasileiros de Cardiologia. 2025. DOI: 10.36660/abc.20240671i

Muzaffer Aslan, Dogac Oksen, Yunus Emre Yavuz, Çağdaş Kaynak. Comparison of Oxidative Stress Effects Between Drug‐Eluting Stents and Drug‐Coated Balloons: Insights Into Vascular Response and Clinical Implications. Catheterization and Cardiovascular Interventions. 2025. DOI: 10.1002/ccd.70209

Muzaffer Aslan, Dogac Oksen, Yunus Emre Yavuz, Cagdas Kaynak. Music Therapy may Decrease Radial Artery Spasm Rates and Increase Satisfaction during Coronary Angiography. Current Vascular Pharmacology. 2025. DOI: 10.2174/0115701611322882250127051550

Oksen D, Gecit MH, Arslan S, Aslan M, Yavuz YE, Secmeler S, Oktay V. Detecting subclinical cardiotoxicity during immune checkpoint inhibitor therapy: a combined GLS and ECG repolarization analysis. Frontiers in oncology. 2025. DOI: 10.3389/fonc.2025.1615209

Dogac Oksen, Muzaffer Aslan, Yunus Emre Yavuz, Cagdas Kaynak, Esra Erturk Tekin. Early detection of ventricular dysfunction in LADA using novel tissue Doppler parameters: A case-control study. Diabetes & Vascular Disease Research. 2025. DOI: 10.1177/14791641251346268

Onur Yolay, Emine Esra Kasapbasi, Erdem Tezcan, Ceyhun Kucuk, Hasan Karaoglu, Emir Canturk, Bekir Inan, Dogac Oksen, Ozge Cetinarslan, Fadil Umihanić et al. Postmortem Inductively Coupled Plasma Mass Spectrometry Analysis Reveals Elevated Heavy Metal Concentrations in Coronary Arteries: A Comparative Autopsy Study Supporting a Toxic Inflammatory Hypothesis for Atherosclerosis. Biomedicine Hub. 2025. DOI: 10.1159/000546499

Çağdaş Kaynak, Muzaffer Aslan, Selim Yazıcı, Dogaç Okşen. The impact of gender differences on the roles of the atherogenic index of plasma and triglyceride-glucose index in predicting moderate to severe coronary artery calcification. The European Research Journal. 2025. DOI: 10.18621/eurj.1664063

Doğaç Okşen, Muzaffer Aslan, Yunus Emre Yavuz. Comparative Prognostic Value of CHA2DS2-VASc Score and Atherogenic Plasma Index for One-year Mortality Prediction in Ischemic Stroke Patients. Bagcilar Medical Bulletin. 2025. DOI: 10.4274/bmb.galenos.2025.57966

Dogac Oksen, Muzaffer Aslan, Ebru Serin, Muhammed Heja Gecit, Yunus Emre Yavuz, Esra Yerlikaya Zerdali, Veysel Oktay. Evaluation of Subclinical Left Ventricular Dysfunction in HIV Patients Receiving Abacavir, Dolutegravir, and Lamivudine Therapy with Novel Tissue Doppler Imaging Techniques. Journal of Clinical Medicine. 2025. DOI: 10.3390/jcm14051534

Dogac Oksen, Muzaffer Aslan, Yunus Emre Yavuz, Necip Nas. Echocardiographic evaluation of subclinical ventricular dysfunction in polycystic ovary syndrome: the role of isovolumic acceleration and myocardial performance index. Journal of Medicine and Palliative Care. 2025. DOI: 10.47582/jompac.1600112

Oksen, D., Aslan, M. Impact of oxidative stress on myocardial performance in patients with diabetes: A focus on subclinical left ventricular dysfunction. BMJ Open Diabetes Research and Care. 2024. DOI: 10.1136/bmjdrc-2024-004153

Oksen, D., Guven, B., Donmez, A., Yesiltas, M.A., Koyuncu, A.O., Gulbudak, S., Oktay, V. Predicting postoperative atrial fibrillation after cardiac surgery using the Naples prognostic score. Coronary Artery Disease. 2024. DOI: 10.1097/MCA.0000000000001438

Bahar Aydınlı, Esra Ertürk Tekin, Mehmet Ali Yeşiltaş, Doğaç Oksen, Harun Özmen. Relationship between Fibrinogen Values and Sensitivity and Specificity of STS Score, Euroscore for Patients Undergoing Open Heart Surgery. The Heart Surgery Forum. 2024. DOI: 10.59958/hsf.8011

Ece Yiğit, Dogac Oksen. Effects of Atrial Fibrıllation on Cognitive Functions in Patients Between 65-75 Years of Age. Hitit Medical Journal. 2024. DOI: 10.52827/hititmedj.1445822

Muzaffer Aslan, Doğaç Okşen, Yunus Emre Yavuz, Çağdaş Kaynak. Atherogenic plasma index is associated with ischemıc cerebrovascular events due to carotid artery disease. Anatolian Current Medical Journal. 2024. DOI: 10.38053/acmj.1448539

Muzaffer Aslan, Yunus Emre Yavuz, Dogac Okşen, Erdem Bal. The relationship of erectile dysfunction severity with nocturnal blood pressure pattern and RDW. Journal of Health Sciences and Medicine. 2024. DOI: 10.32322/jhsm.1476358

Ece YİĞİT, Doğaç OKŞEN, Sema BASAT. 65-75 Yaş Arası Hastalarda Kardiyovasküler Risk ve Kırık Riski Arasındaki İlişkinin Değerlendirilmesi. Istanbul Yeni Yuzyil Universitesi, Yeni Yuzyil Journal of Medical Sciences. 2024. DOI: 10.46629/JMS.2024.147

Tekin, E.E., Aydinli, B., Yesiltas, M.A., Oksen, D. Emergency coronary artery bypass surgery in octogenarians with acute coronary syndrome: off and on pump. European Review for Medical and Pharmacological Sciences. 2023. DOI: 10.26355/eurrev_202308_33277

Aslan, M., Oksen, D., Kaynak, C., Ozudogru, O. Impact of empagliflozin on left atrial mechanical and conduction functions in patients with type 2 diabetes mellitus. Journal of Clinical Ultrasound. 2023. DOI: 10.1002/jcu.23384

Oksen, D., Aslan, M., Ozmen, E., Yavuz, Y.E. Ranolazine improved left ventricular diastolic functions and ventricular repolarization indexes in patients with coronary slow flow. Frontiers in Cardiovascular Medicine. 2023. DOI: 10.3389/fcvm.2023.1207580

Mert Sarilar, Veysel Oktay, Gursu Demirci, Dogac Oksen, Vedat Sansoy. Periprocedural myocardial injury after elective percutaneous coronary intervention in stable angina pectoris: a tertiary center experience. Cor et Vasa. 2023. DOI: 10.33678/cor.2022.111

Haberal, I., Balli, M., Tekin, E.E., Uysal, A., Ozsoy, S.D., Yesiltas, M.A., Oksen, D., Batur, S., Ak, H.Y., Aydinli, B. SYNTAX and Coronary Artery Calcium Score Predict Atherosclerotic Plaque Formation in the Ascending Aorta. Heart Surgery Forum. 2021. DOI: 10.1532/hsf.4233

Celebi˙, G., Guclu Geyi˙K, F., Yilmazbayhan, D., Ozsoy, D., Yildiz, C.E., Yildiz, M., Oksen, D., Cavlak, M., Komurcu Bayrak, E. THE RELATIONSHIP BETWEEN THE EXPRESSION LEVELS OF TISSUE INHIBITOR OF METALLOPROTEINASES-3 (TIMP3) AND SEVERITY OF ATHEROSCLEROSIS,METALLOPROTEİNAZ-3 DOKU İNHİBİTORUNUN (TIMP3) İFADE DUZEYLERİ İLE ATEROSKLEROZUN ŞİDDETİ ARASINDAKİ İLİŞKİ. Istanbul Tip Fakultesi Dergisi. 2021. DOI: 10.26650/IUITFD.2021.896230

Dogac Oksen, Mert Sarilar, Gursu Demirci, Ismail Haberal, Okay Abaci. In-hospital and long-term outcomes of ST-segment elevation myocardial infarction patients undergoing primary percutaneous coronary intervention. Koşuyolu Heart J. 2022;25(1):23–32. DOI: 10.51645/khj.2021.m54

Oktay V, Keskin B, Serin E, Oksen D, Kaya A, Ozkan AA. Comparison of transradial versus transfemoral diagnostic coronary angiography in terms of oxidative stress: Which option is more physiological? European Journal of Inflammation. January 2021. doi:10.1177/20587392211028073.

Yilmaz Ak H, Özşahin Y, Yesiltas MA, Haberal İ, Kahraman S, Oksen D, Yildiz M. Comparison of Demographic Profile, Laboratory, Epidemiology and Clinical Outcomes in Patients with Native Valve and Prosthetic Valve Endocarditis. Heart Surg Forum. 2021 Jun 11;24(3): E534-E543. doi: 10.1532/hsf.3715. PMID: 34173758.

Sit O, Oksen D, Atici A, Barman HA, Alici G, Pala AS, Tekin EA, Meke A, Borahan S, Gungor B. Prognostic significance of Tp-e interval and Tp-e/QTc ratio in patients with COVID-19. Eur Rev Med Pharmacol Sci. 2021 Apr;25(8):3272-3278. doi: 10.26355/eurrev_202104_25736. PMID: 33928614.

Kalkan ME, Yildiz M, Ak HY, Zencirkiran Agus H, Ozsahin Y, Aykan AC, Oksen D. Safety of low-dose prolonged infusion of tissue plasminogen activator therapy in patients with thromboembolic events in the intensive care unit. Kardiologiia. 2020 Aug 11;60(7):86-90. doi: 10.18087/cardio.2020.7.n1091. PMID: 33155945.4.

Mustafa Yıldız, Gözde Mümi̇n, Doğaç Okşen, Sinan Oral. Principles and Techniques of the Three-Dimensional Electroanatomic Cardiac Mapping Approach in the Treatment of Intractable Atrial Macroreentrant Tachycardia Ablations. Koşuyolu Heart J. 2018; 21(2): 108-110. doi:10.5578/khj.66206.

Hülya Yılmaz Ak, Mustafa Yıldız, Nurgül Yurtseven, Deniz Özsoy, Doğaç Okşen, Hakkı Kürşat Çeti̇n. Relation of Troponin I Levels with Postoperative Mortality and Morbidity Rates in Patients Followed in Intensive Care Unit After Congenital Cardiac Surgery Whose Ages Between 7 Days and 16 Years Old. Koşuyolu Heart J. 2018; 21(1): 043-048. doi:10.5578/khj.60771.

Yildiz M, Yilmaz Ak H, Oksen D, Oral S. Anesthetic Management In Electrophysiology Laboratory: A Multidisciplinary Review. J Atr Fibrillation. 2018 Feb 28;10(5):1775. doi: 10.4022/jafib.1775. PMID: 29988243; PMCID: PMC6006978.

Yildiz M, Oksen D, Behnes M, Akin I. Contribution and Value of Biomarkers in Acute Aortic Syndromes. Curr Pharm Biotechnol. 2017;18(6):495-498. doi: 10.2174/1389201018666170615081727. PMID: 28641567.

Mustafa Yildiz, Yasemin Ozsahin, Hulya Yilmaz Ak, Dogac Oksen. Isolated right ventricular noncompaction in an adult woman with severe pulmonary hypertension following at the intensive care unit. Koşuyolu Heart J. 2021;24(3):249–251. DOI: 10.51645/khj.2021.m148

Ece Yiğit, Dogac Oksen, Sema Basat. EVALUATION OF THE RELATIONSHIP BETWEEN CARDIOVASCULAR RISK AND FRACTURE RISK IN PATIENTS AGED 65-75. 3rd INTERNATIONAL CONGRESS OF MULTIDISCIPLINARY STUDIES IN MEDICAL SCIENCES August 17, 2021 / Ankara, TURKEY.

Dogac Oksen, Veysel Oktay. INFLUENCE OF E-CIGARETTE SMOKING ON VENTRICULAR REPOLARIZATION DISPERSION ON HEALTHY INDIVIDUALS. 16th International Update in Cardiology and Cardiovascular Surgery (UCCVS) Congress. 30 October - 1 November 2020, Antalya, Turkey.

Dogac Oksen, Ecem Oksen, Gozde Mumin, Sukru Arslan. Evaluation of supraventricular arrhythmias among women undergoing controlled ovarian stimulation before in vitro fertilization. 36th Turkish Cardiology Congress with International Participation. 3 – 6 December 2020, Antalya, Turkey. Anatol J Cardiol, Vol: 24, (Suppl 1), December 2020.

Dogac Oksen, Mehmet Emin Gokce, Ayca Donmez, Gursu Demirci, Sukru Arslan. Impact of Sacubitril – Valsartan on Sleep Quality in Patients with Congestive Heart Failure. 36th Turkish Cardiology Congress with International Participation. 3 – 6 December 2020, Antalya, Turkey. Anatol J Cardiol, Vol: 24, (Suppl 1), December 2020.

Dogac Oksen, Esra Zerdeli, Ebru Serin, Bengisu Keskin, Inci Yilmaz Nakir, Zubeyir Bulat, Mert Sarilar, Veysel Oktay. Assessment of subtle left ventricular dysfunction by two dimensional strain echocardiography of HIV-1 positive individuals receiving highly active antiretroviral therapy. 36th Turkish Cardiology Congress with International Participation. 3 – 6 December 2020, Antalya, Turkey. Anatol J Cardiol, Vol: 24, (Suppl 1), December 2020.

Evrim Kömürcü Bayrak, Hilal Şentürk, Doğaç Okşen, Cenk Eray Yıldız, Mustafa Yıldız. The importance of ANRIL expression levels in blood leukocytes of the patients with acute coronary syndrome. Anatol J Cardiol 2019; 22 (Suppl 1): 1-120. 35th Turkish Cardiology Congress with International Participation. 3 – 6 October 2019.

Doğaç Oksen, Mert Sarılar, Veysel Oktay. Is it really necessary to say whether octogenarians to stay in the coronary intensive care unit? Anatol J Cardiol 2018; 20 (Suppl 1): 1-155. 34th Turkish Cardiology Congress with International Participation. 20 – 23 October 2018.

Hilal Senturk, Dogac Oksen, Deniz Ozsoy, Ekrem Bilal Karaayvaz, Cenk Eray Yildiz, Mustafa Yildiz, Evrim Komurcu Bayrak1 The importance of two candidate long non coding RNA expression levels on acute myocardial infarction. Anatol J Cardiol 2018; 20 (Suppl 1): 1-155. 34th Turkish Cardiology Congress with International Participation. 20 – 23 October 2018.

Hakan Kaptanogullari, Veysel Oktay, Dogac Oksen, Vefa Celenk, Ilknur Cirali, Mustafa Yildiz. Acute effects of ultrafiltration on arterial stiffness index ß and elastic modulus in chronic hemodialysis patients. Anatol J Cardiol 2018; 20 (Suppl 1): 1-155. 34th Turkish Cardiology Congress with International Participation. 20 – 23 October 2018.

Veysel Oktay, Doğaç Oksen, Mert Sarılar, Cüneyt Koçaş, Ahmet Yıldız. Guiding catheter induced left main coronary artery dissection treated by successfully bail-out coronary stenting. 34th Turkish Cardiology Congress with International Participation. 20 – 23 October 2018.

Mustafa Yıldız, İbrahim Akın, Dogac Oksen, Christian Fastner, Michael Behnes, Kambis Mashayekhi, Ibrahim El Battrawy, Ralf Lehmann, Stefan Baumann, Tobias Becher, Martin Borggrefe. The left atrial appendage closure with a percutaneous path: Operative, in-hospital and echocardiographic outcomes. Anatol J Cardiol 2017; 18 (Suppl 1): 1-109. 33th TSC Abstracts/ORALS, 5 – 8 October 2017.

Nuh Nazmi Gultekin, Ebru Serin, Dogac Oksen, Veysel Oktay, Kiymet Muammer. A Case Report: Idiopathic Progressive Polyneuropathy Accompanied by Countless Times of Acute Pulmonary Edema. 33th Turkish Cardiology Congress with International Participation. 5 – 8 October 2017.

Dogac Oksen, Mert Sarilar, Gursu Demirci, Gkiozde Moumin, Inci Firatli. Reversable third - degree atrioventricular block induced by mirtazapine: a case report. 33th Turkish Cardiology Congress with International Participation. 5 – 8 October 2017.

Mustafa Yildiz, Dogac Oksen, Gkiozde Moumin, Bengisu Keskin, Okay Abaci, Nazire Baskurt Aladag. Familial hypercholesterolemia patient: determined coronary plaque in real time 2D and 3D transthoracic echocardiography. 33th Turkish Cardiology Congress with International Participation. 5 – 8 October 2017.

Veysel Oktay, Ebru Serin, Dogac Oksen, Emir Baris Okcun. Right atrial mass: myxoma causing right heart failure. 33th Turkish Cardiology Congress with International Participation. 5 – 8 October 2017.

Ayşem Kaya, Özge Kılçarslan, Mert Palabıyık, Ümit Yaşar Sinan, Doğaç Okşen, Bengisu Keskin, Alev Arat Özkan. Implementation of Lipid Guidelines in Daily Clinical Practice. Anatol J Cardiol 2016; 16 (Suppl 1): 1-104. TSC Abstracts/ORALS October 20-23, 2016.

Doğaç Okşen, Bengisu Keskin, Yalçın Dalgıç, Okay Abacı, Alev Arat Özkan. Ischaemia induced preexitation resolved by ranalozine. 32th Turkish Cardiology Congress with International Participation. 20 – 23 October 2016.

Bengisu Keskin Meriç, Ümit Yaşar Sinan, Doğaç Okşen, Rukiye Yıldırım, Veysel Oktay, Okay Abacı, Mehmet Serdar Küçükoğlu. Kuadriküspit aort kapak: Nadir bir konjenital vaka. 36th Turkish Cardiology Congress with International Participation. 3- 6 Aralık 2020, Antalya.

Dogac Oksen, Ebru Serin, Gürsu Demirci, Mehmet Tugay Yumuk, Veysel Oktay. Diagnostic Catheter Induced Spiral Dissection Treated by Successfully Bail-Out Coronary Stenting. 27. Ulusal Uygulamalı Girişimsel Kardiyoloji Toplantısı. 12 – 15 Kasım 2020.

Dogac Oksen, Veysel Oktay. Perkütan Koroner Girişim Sonrası Üçlü Tedavi Alan Hastaları Gastrointestinal Kanamadan Nasıl Koruyalım ? Sağlık Bilimleri Üniversitesi 3. Gastroenteroloji Günleri. 19 – 20 Nisan 2019, İstanbul.

Veysel OKTAY, Dogac OKSEN, Mert SARİLAR, Bengisu KESKİN, Vedat SANSOY. SİSTEMATİK KORONER RİSK HESAPLAMASI (SCORE) SİSTEMİNİN ÖLÜMCÜL KARDİYOVASKÜLER HASTALIK RİSKİNİN BELİRLENMESİNDEKİ ROLÜ. Kardiyovasküler Akademi Kış Kongresi. 14 – 17 Mart 2019, Uludağ.

Mustafa Yildiz, Ibrahim Akin, Dogac Oksen, Hicaz Zencikar Agus, Begum Uygur, Gokhan Demirci, Fatih Uzun, Ali Kemal Kalkan. Percutaneous Left Atrial Appendage Closure Using Double Device. 25. Uygulamalı Girişimsel Kardiyoloji Kongresi, 3 – 6 Mayıs 2018, Antalya. (Sözlü Bildiri).

Hilal Şentürk, Doğaç Okşen, Deniz Özsoy, Ekrem Bilal Karaayvaz, Cenk Eray Yıldız, Mustafa Yıldız, Evrim Kömürcü-Bayrak. Miyokard Enfarktüsü Geçirmiş Erkek Hastalarda Kodlamayan RNA BAT5 ifade Düzeyleri. X. Aziz Sancar DETAE Günleri, 29-30 Kasım 2018, Istanbul, Turkey. (Özet Bildiri/Poster).

Mustafa Yildiz, Sait Mesut Dogan, Ismail Haberal, Umit Yasar Sinan, Dogac Oksen, Hicaz Zencirkiran Agus, Begum Uygur, Mehmet Emin Kalkan. Successful Treatment of Dump Bell Abdominal Aortic Aneurysm Just Below Renal Arteries. 25. Uygulamalı Girişimsel Kardiyoloji Kongresi, 3 – 6 Mayıs 2018, Antalya. (Özet Bildiri/Poster)

Mustafa Yildiz, Dogac Oksen, Ibrahim Akin. (2017). Cardiogenic Shock Due to Coronary Artery Stent Thrombosis. DOI: 10.5772/intechopen.68362.

Исследователь: C.E. Yildiz, M. Yildiz, G. Moumin, D. Oksen, A.E. Bayrak, F. Geyik, G. Celebi. Университетский проект об экспрессии микроРНК-125b и микроРНК-142 и тяжести атеросклероза после недавнего инфаркта миокарда, 2017–2019.

Исследователь: M. Yildiz, B. Keskin, A.E. Bayrak, D. Oksen, H. Yilmaz Ak, N. Coban. Университетский проект об уровне ANRIL в крови при диагностике и наблюдении острого коронарного синдрома, 2018–2020.

Statini Tolere Edemeyen ve Kardiyovasküler Hastalığı Bulunan ya da Kardiyovasküler Hastalik İçin Yüksek Riskli Olan Hastalarda, Major Kardiyovaskuler Olaylarin İnsidansinda Bempedoik Asidin (ETC 1002) Etkilerinin Değerlendirildiği Randomize, Çift Kör, Plasebo Kontrollü Çalışma FAZ III Çalışması. Protokol Numarası 1002- 043, 2017.

A Double-blind, Randomized, Placebo-controlled, Multicenter Study to Assess the Efficacy and Safety of Omecamtiv Mecarbil on Mortality and Morbidity in Subjects with Chronic Heart Failure with Reduced Ejection Fraction (GALACTIC-HF) ClinicalTrials.gov Identifier: NCT02929329, July 20, 2021.

A Multicenter, Randomized, Double-blind, Parallel Group, Active-controlled Study to Evaluate the Efficacy and Safety of LCZ696 Compared to Valsartan, on Morbidity and Mortality in Heart Failure Patients (NYHA Class II-IV) With Preserved Ejection Fraction (PARAGON-HF). Protocol Identifier: LCZ696D2301, June 7, 2019.

A Randomized, Double-blind, Event-driven, Multicenter Study Comparing the Efficacy and Safety of Rivaroxaban with Placebo for Reducing the Risk of Death, Myocardial Infarction or Stroke in Subjects With Heart Failure and Significant Coronary Artery Disease Following an Episode of Decompensated Heart Failure (RIVAROXHFA3001), April 19, 2018.

Kalp yetmezliği ve korunmuş ejeksiyon fraksiyonu olan hastalarda komorbiditelerin bireyselleştirilmiş medikal yönetimine kıyasla LCZ696' nın NT-proBNP, semptomlar, egzersiz fonksiyonu ve güvenlilik üzerindeki etkisini değerlendirmek üzere yürütürlen 24 haftalık, randomize, çift kör, çok merkezli, paralel gruplu aktif kontrollü bir çalışma