Prof. Dr. Ali Ayberk Beşen

Медицинский факультет Джеррахпаша Стамбульского университета — Медицинское образование

Университет Чукурова — Специализация

Субспециализация по медицинской онкологии

2023– — Больница Medical Park Seyhan

2016–2023 — Учебно-исследовательский центр Университета Башкент в Адане

2016 — Учебно-исследовательская больница Университета Реджепа Тайипа Эрдогана, Ризе

2013–2014 — Учебно-исследовательская больница Ван

2009–2013 — Учебно-исследовательский центр Университета Башкент в Адане

Рак желудка и толстой кишки

Гинекологические опухоли

Лимфомы и опухоли головного мозга

Опухоли простаты, мочевого пузыря и почек

Рак кожи

Efil SC, Kus F, Koylu B, Durukan BM, Bayram S, Guzel HG, Ozturk B, Muglu H, Bilici A, Kose F, Alan O, Karapelit Agitoglu E, Guner G, Besen AA, Helvaci K, Araz M, Kacan T, Arslan C, Unal A, Eniseler EB, Biter S, Ekinci F, Aslan F, Unek IT, Tas S, Acar O, Ates O, Sakalar T, Akbas S, Karakas H, Akinci MB, Yalcin B, Yalcin S, Sendur MAN. Durvalumab-Based First-Line Chemoimmunotherapy in Advanced Biliary Tract Cancer: Real-World Outcomes and Prognostic Factors-A Turkish Oncology Group Study. Cancers (Basel). 2025 Dec 29;18(1):101. doi: 10.3390/cancers18010101.

Takashima A, García-Alfonso P, Manneh R, Beşen AA, Hong YS, Cuyle PJ, Yanez P, Burge M, Yoshino T, Kim TW, Cui K, Li C, Jain R, Adelberg D, Taieb J. Olaparib with or without bevacizumab versus bevacizumab plus a fluoropyrimidine as maintenance therapy in advanced colorectal cancer: The randomized phase 3 LYNK-003 study. Eur J Cancer. 2024 Jul;205:114036. doi: 10.1016/j.ejca.2024.114036. Epub 2024 Mar 21.

Somay E, Topkan E, Kucuk A, Ozturk D, Ozkan EE, Ozdemir BS, Besen AA, Mertsoylu H, Pehlivan B, Selek U. Pre-chemoradiotherapy high platelet counts predict jaw osteoradionecrosis in locally advanced nasopharyngeal carcinoma patients. J Stomatol Oral Maxillofac Surg. 2024 Jun;125(3S):101838. doi: 10.1016/j.jormas.2024.101838. Epub 2024 Mar 20.

Somay E, Yilmaz B, Topkan E, Ozdemir BS, Ozturk D, Besen AA, Mertsoylu H, Selek U. Worth of pan-immune-inflammation value in trismus prediction after concurrent chemoradiotherapy for nasopharyngeal carcinomas. Int J Biol Markers. 2024 Mar;39(1):80-88. doi: 10.1177/03936155231223198. Epub 2024 Jan 8.

Kucuk A, Topkan E, Selek U, Haksoyler V, Mertsoylu H, Besen AA, Pehlivan B. High Measures of Pre-Chemoradiotherapy Platelet-to-Albumin Ratio Indicates Poor Prognosis in Locally Advanced Pancreatic Cancer Patients. Ther Clin Risk Manag. 2022 Apr 14;18:421-428. doi: 10.2147/TCRM.S359553. eCollection 2022.

Somay E, Yilmaz B, Topkan E, Ozdemir BS, Ozturk D, Besen AA, Mertsoylu H, Selek U. Novel Index Combining Pan-Immune-Inflammatory Index and Hemoglobin Levels (PIV/Hb) Predicts Trismus Rates Efficiently after Chemoradiotherapy in Locally Advanced Nasopharyngeal Cancer. Int J Surg Oncol. 2024 Sep 30;2024:2124006. doi: 10.1155/2024/2124006. eCollection 2024.

Topkan E, Kucuk A, Ozkan EE, Ozturk D, Besen AA, Mertsoylu H, Pehlivan B, Selek U. High pre-chemoradiotherapy pan-immune-inflammation value levels predict worse outcomes in patients with stage IIIB/C non-small-cell lung cancer. Discov Oncol. 2023 Dec 13;14(1):230. doi: 10.1007/s12672-023-00851-8.

Somay E, Topkan E, Yilmaz B, Besen AA, Mertsoylu H, Selek U. Predicting Teeth Extraction after Concurrent Chemoradiotherapy in Locally Advanced Nasopharyngeal Cancer Patients Using the Novel GLUCAR Index. Diagnostics (Basel). 2023 Dec 4;13(23):3594. doi: 10.3390/diagnostics13233594.

Pehlivan UA, Somay E, Yilmaz B, Besen AA, Mertsoylu H, Selek U, Topkan E. Pretreatment Masseter Muscle Volume Predicts Survival in Locally Advanced Nasopharyngeal Carcinoma Patients Treated with Concurrent Chemoradiotherapy. J Clin Med. 2023 Oct 30;12(21):6863. doi: 10.3390/jcm12216863.

Topkan E, Kucuk A, Ozturk D, Ozkan EE, Besen AA, Pehlivan B, Selek U. Prognostic Value of Novel CARWL Score in Stage IIIC Non-Small-Cell Lung Cancer Patients Undergoing Concurrent Chemoradiotherapy. Can Respir J. 2024 Jun 28;2024:2803044. doi: 10.1155/2024/2803044. eCollection 2024.

Topkan E, Somay E, Besen AA, Mertsoylu H. Letter to Editor: "The Trajectory of Oral Mucositis in Head and Neck Cancer Patients Undergoing Radiotherapy and Its Influencing Factors". Ear Nose Throat J. 2024 Apr 24:1455613241249268. doi: 10.1177/01455613241249268. Online ahead of print.

Topkan E, Kilic Durankus N, Senyurek S, Öztürk D, Besen AA, Mertsoylu H, Pehlivan B, Selek U. The global immune-nutrition-inflammation index (GINI) as a robust prognostic factor in glioblastoma patients treated with the standard stupp protocol. Int J Immunopathol Pharmacol. 2024 Jan-Dec;38:3946320241284089. doi: 10.1177/03946320241284089.

Yilmaz B, Somay E, Topkan E, Pehlivan B, Besen AA, Mertsoylu H, Selek U. Predictive potential of pan-immune-inflammation value / hemoglobin index as biomarker for osteoradionecrosis risk in locally advanced nasopharyngeal carcinomas. J Stomatol Oral Maxillofac Surg. 2024 Dec;125(6):101786. doi: 10.1016/j.jormas.2024.101786. Epub 2024 Jan 28.

Topkan E, Selek U, Pehlivan B, Kucuk A, Ozturk D, Ozdemir BS, Besen AA, Mertsoylu H. The Prognostic Value of the Novel Global Immune-Nutrition-Inflammation Index (GINI) in Stage IIIC Non-Small Cell Lung Cancer Patients Treated with Concurrent Chemoradiotherapy. Cancers (Basel). 2023 Sep 11;15(18):4512. doi: 10.3390/cancers15184512.

Somay E, Topkan E, Pehlivan UA, Yilmaz B, Besen AA, Mertsoylu H, Pehlivan B, Selek U. The Use of Pre-Chemoradiotherapy Total Masseter Muscle Volume as a Novel Predictor of Radiation-Induced Trismus in Locally Advanced Nasopharyngeal Carcinoma Patients. Tomography. 2024 Jan 10;10(1):79-89. doi: 10.3390/tomography10010007.

Ilhan Y, Tatli AM, Teker F, Onder AH, Kose F, Geredeli C, Karaagac M, Kaplan MA, Inanc M, Goktas Aydin S, Kargi A, Arak H, Ozturk B, Besen AA, Selvi O, Korkmaz M, Oruc Z, Bozkurt O, Bilici A, Bayram S, Dae SA, Ozdogan M, Coskun HS, Sezgin Goksu S. Cisplatin plus paclitaxel and bevacizumab versus carboplatin plus paclitaxel and bevacizumab for the first-line treatment of metastatic or recurrent cervical cancer. Int J Gynecol Cancer. 2022 Apr 4;32(4):502-507. doi: 10.1136/ijgc-2021-003165.

Topkan E, Somay E, Besen AA, Mertsoylu H. Comment on: Does the Planning Target Volume Correlate with Toxicity for Head and Neck Cancer Patients Undergoing Radiation? A Prospective Observational Study. Indian J Surg Oncol. 2024 Sep;15(Suppl 3):481-482. doi: 10.1007/s13193-024-02045-2. Epub 2024 Jul 28.

Ozdemir Y, Torun N, Guler OC, Yildirim BA, Besen AA, Yetisken AG, Onal HC, Topkan E. Local control and vertebral compression fractures following stereotactic body radiotherapy for spine metastases. J Bone Oncol. 2019 Jan 24;15:100218. doi: 10.1016/j.jbo.2019.100218. eCollection 2019 Apr.

Yildirim BA, Onal C, Kose F, Oymak E, Sedef AM, Besen AA, Aksoy S, Guler OC, Sumbul AT, Muallaoglu S, Mertsoylu H, Ozyigit G. Outcome of loco-regional radiotherapy in metastatic castration-resistant prostate cancer patients treated with abiraterone acetate. Strahlenther Onkol. 2019 Oct;195(10):872-881. doi: 10.1007/s00066-019-01429-6. Epub 2019 Jan 30.

Topkan E, Yucel Ekici N, Ozdemir Y, Besen AA, Mertsoylu H, Sezer A, Selek U. Baseline Low Prognostic Nutritional Index Predicts Poor Survival in Locally Advanced Nasopharyngeal Carcinomas Treated With Radical Concurrent Chemoradiotherapy. Ear Nose Throat J. 2021 Feb;100(2):NP69-NP76. doi: 10.1177/0145561319856327. Epub 2019 Jun 10.

Topkan E, Kucuk A, Ozdemir Y, Mertsoylu H, Besen AA, Sezen D, Bolukbasi Y, Pehlivan B, Selek U. Systemic Inflammation Response Index Predicts Survival Outcomes in Glioblastoma Multiforme Patients Treated with Standard Stupp Protocol. J Immunol Res. 2020 Nov 14;2020:8628540. doi: 10.1155/2020/8628540. eCollection 2020.

Topkan E, Selek U, Kucuk A, Haksoyler V, Ozdemir Y, Sezen D, Mertsoylu H, Besen AA, Bolukbasi Y, Ozyilkan O, Pehlivan B. Prechemoradiotherapy Systemic Inflammation Response Index Stratifies Stage IIIB/C Non-Small-Cell Lung Cancer Patients into Three Prognostic Groups: A Propensity Score-Matching Analysis. J Oncol. 2021 Jan 23;2021:6688138. doi: 10.1155/2021/6688138. eCollection 2021.

Topkan E, Besen AA, Ozdemir Y, Kucuk A, Mertsoylu H, Pehlivan B, Selek U. Prognostic Value of Pretreatment Systemic Immune-Inflammation Index in Glioblastoma Multiforme Patients Undergoing Postneurosurgical Radiotherapy Plus Concurrent and Adjuvant Temozolomide. Mediators Inflamm. 2020 May 23;2020:4392189. doi: 10.1155/2020/4392189. eCollection 2020.

Kose F, Alemdaroglu S, Mertsoylu H, Besen AA, Guler OC, Simsek SY, Erbay G, Onal C, Celik H. Half-dose bevacizumab experience in relapsed ovarian cancer patients in Turkey due to formal regulations: similar effectiveness with lower rate of hypertension. J BUON. 2020 Jul-Aug;25(4):1928-1934.

Topkan E, Ozdemir Y, Guler OC, Kucuk A, Besen AA, Mertsoylu H, Sezen D, Akdemir EY, Sezer A, Bolukbasi Y, Pehlivan B, Selek U. Comparison of Involved Field Radiotherapy versus Elective Nodal Irradiation in Stage IIIB/C Non-Small-Cell Lung Carcinoma Patients Treated with Concurrent Chemoradiotherapy: A Propensity Score Matching Study. J Oncol. 2020 Sep 4;2020:7083149. doi: 10.1155/2020/7083149. eCollection 2020.

Göksu SS, Tatlı AM, Geredeli Ç, Atcı M, Besen AA, Mertsoylu H, Uysal M, Özdoğan M, Aydın SG, Bilici A, Karaağaç M, Artaç M, Kaplan MA, Ebinç S, Coşkun HŞ. Cetuximab-induced rash is associated with overall survival in patients with recurrent/metastatic squamous cell carcinoma of head and neck. Cancer Chemother Pharmacol. 2021 Nov;88(5):805-812. doi: 10.1007/s00280-021-04328-9. Epub 2021 Jul 26.

Topkan E, Ozdemir Y, Kucuk A, Besen AA, Mertsoylu H, Sezer A, Selek U. Significance of overall concurrent chemoradiotherapy duration on survival outcomes of stage IIIB/C non-small-cell lung carcinoma patients: Analysis of 956 patients. PLoS One. 2019 Jul 22;14(7):e0218627. doi: 10.1371/journal.pone.0218627. eCollection 2019.

Onal C, Sedef AM, Kose F, Oymak E, Guler OC, Sumbul AT, Aksoy S, Akkus Yildirim B, Besen AA, Muallaoglu S, Mertsoylu H, Ozyigit G. The hematologic parameters in metastatic castration-resistant prostate cancer patients treated with abiraterone acetate. Future Oncol. 2019 May;15(13):1469-1479. doi: 10.2217/fon-2018-0635. Epub 2019 Apr 12.

Topkan E, Selek U, Ozdemir Y, Yildirim BA, Guler OC, Ciner F, Besen AA, Findikcioglu A, Ozyilkan O. Incidence and Impact of Pretreatment Tumor Cavitation on Survival Outcomes of Stage III Squamous Cell Lung Cancer Patients Treated With Radical Concurrent Chemoradiation Therapy. Int J Radiat Oncol Biol Phys. 2018 Aug 1;101(5):1123-1132. doi: 10.1016/j.ijrobp.2018.04.053. Epub 2018 Apr 26.

Topkan E, Mertsoylu H, Kucuk A, Besen AA, Sezer A, Sezen D, Bolukbasi Y, Selek U, Pehlivan B. Low Systemic Inflammation Response Index Predicts Good Prognosis in Locally Advanced Pancreatic Carcinoma Patients Treated with Concurrent Chemoradiotherapy. Gastroenterol Res Pract. 2020 Jul 30;2020:5701949. doi: 10.1155/2020/5701949. eCollection 2020.

Topkan E, Besen AA, Mertsoylu H, Kucuk A, Pehlivan B, Selek U. Prognostic Value of C-Reactive Protein to Albumin Ratio in Glioblastoma Multiforme Patients Treated with Concurrent Radiotherapy and Temozolomide. Int J Inflam. 2020 Jun 8;2020:6947382. doi: 10.1155/2020/6947382. eCollection 2020.

Topkan E, Mertsoylu H, Ozdemir Y, Sezer A, Kucuk A, Besen AA, Ozyilkan O, Selek U. Prognostic Usefulness Of Advanced Lung Cancer Inflammation Index In Locally-Advanced Pancreatic Carcinoma Patients Treated With Radical Chemoradiotherapy. Cancer Manag Res. 2019 Oct 7;11:8807-8815. doi: 10.2147/CMAR.S222297. eCollection 2019.

Topkan E, Ekici NY, Ozdemir Y, Besen AA, Yildirim BA, Mertsoylu H, Sezen D, Selek U. Baseline hemoglobin <11.0 g/dL has stronger prognostic value than anemia status in nasopharynx cancers treated with chemoradiotherapy. Int J Biol Markers. 2019 Jun;34(2):139-147. doi: 10.1177/1724600818821688. Epub 2019 Mar 13.

Topkan E, Ozdemir Y, Kucuk A, Guler OC, Sezer A, Besen AA, Mertsoylu H, Senyurek S, Kilic Durankus N, Bolukbasi Y, Selek U, Pehlivan B. Low Advanced Lung Cancer Inflammation Index Predicts Poor Prognosis in Locally Advanced Nasopharyngeal Carcinoma Patients Treated with Definitive Concurrent Chemoradiotherapy. J Oncol. 2020 Oct 7;2020:3127275. doi: 10.1155/2020/3127275. eCollection 2020.

Topkan E, Bolukbasi Y, Ozdemir Y, Besen AA, Mertsoylu H, Selek U. Prognostic value of pretreatment Glasgow prognostic score in stage IIIB geriatric non-small cell lung cancer patients undergoing radical chemoradiotherapy. J Geriatr Oncol. 2019 Jul;10(4):567-572. doi: 10.1016/j.jgo.2018.10.014. Epub 2018 Oct 26.

Mertsoylu H, Muallaoglu S, Besen AA, Erdogdu S, Sezer A, Sedef AM, Kose F, Arican A, Ozyilkan O. Primary extranodal non-Hodgkin's lymphoma: clinicopathological features, survival and treatment outcome in two cancer centers of southern Turkey. Asian Pac J Cancer Prev. 2014;15(17):7207-11. doi: 10.7314/apjcp.2014.15.17.7207.

Sozutek A, Irkorucu O, Reyhan E, Yener K, Besen AA, Erdogan KE, Gonlusen G, Doran F. A Giant Aggressive Angiomyxoma of the Pelvis Misdiagnosed as Incarcerated Femoral Hernia: A Case Report and Review of the Literature. Case Rep Surg. 2016;2016:9256749. doi: 10.1155/2016/9256749. Epub 2016 May 5.

Muallaoglu S, Besen AA, Ata A, Mertsoylu H, Arican A, Kayaselcuk F, Ozyilkan O. Lack of prognostic significance of C-erbB-2 expression in low- and high- grade astrocytomas. Asian Pac J Cancer Prev. 2014;15(3):1333-7. doi: 10.7314/apjcp.2014.15.3.1333.

Topkan E, Selek U, Ozdemir Y, Besen AA, Guler OC, Yildirim BA, Mertsoylu H, Findikcioglu A, Ozyilkan O, Pehlivan B. Risk Factors for Fatal Pulmonary Hemorrhage following Concurrent Chemoradiotherapy in Stage 3B/C Squamous-Cell Lung Carcinoma Patients. J Oncol. 2018 Nov 1;2018:4518935. doi: 10.1155/2018/4518935. eCollection 2018.

Topkan E, Selek U, Mertsoylu H, Ozdemir Y, Kucuk A, Torun N, Besen AA. Pretreatment Photopenia on 18F-Fluorodeoxyglucose Positron Emission Tomography-Computed Tomography Scans Predicts Poor Prognosis in Nasopharyngeal Cancer Patients Undergoing Concurrent Chemoradiotherapy. Clin Exp Otorhinolaryngol. 2020 Nov;13(4):407-414. doi: 10.21053/ceo.2019.01298. Epub 2020 Feb 21.

Mertsoylu H, Köse F, Sümbül AT, Sedef AM, Doğan Ö, Besen AA, Parlak C, Fındıkçıoğlu A, Muallaoğlu S, Sezer A, Sakallı H, Özyılkan Ö. Concurrent chemoradiotherapy with vinorelbine plus split-dose cisplatin may be an option in inoperable stage III non-small cell lung cancer: a single-center experience. Med Sci Monit. 2015 Mar 3;21:661-6. doi: 10.12659/MSM.892730.

Tatli AM, Besen AA, Kalender ME, Uysal M, Aslan D, Goksu SS, Gunduz SG, Coskun HS. Association of vitiligo and response in patients with metastatic malignant melanoma on temozolomide. Tumori. 2015 Mar-Apr;101(2):e67-9. doi: 10.5301/je.5000253.

Abali H, Sezer A, Oğuzkurt L, Gürel K, Özkan U, Beşen AA, Sümbül AT, Köse F, Dişel U, Muallaoğlu S, Özyılkan Ö. Which patients with advanced cancer and biliary obstruction benefit from biliary stenting most? An analysis of prognostic factors. Support Care Cancer. 2013 Apr;21(4):1131-5. doi: 10.1007/s00520-012-1636-z. Epub 2012 Nov 8.

Dişel U, Beşen AA, Özyılkan Ö, Er E, Canpolat T. A case report of bevacizumab-related osteonecrosis of the jaw: old problem, new culprit. Oral Oncol. 2012 Feb;48(2):e2-3. doi: 10.1016/j.oraloncology.2011.07.030. Epub 2011 Aug 23.

Dişel U, Oztuzcu S, Beşen AA, Karadeniz C, Köse F, Sümbül AT, Sezer A, Nursal GN, Abalı H, Ozyılkan O. Promising efficacy of sorafenib in a relapsed thymic carcinoma with C-KIT exon 11 deletion mutation. Lung Cancer. 2011 Jan;71(1):109-12. doi: 10.1016/j.lungcan.2010.09.011.

Sumbul AT, Sezer A, Abali H, Dicel U, Gultepe I, Besen AA, Ozyilkan O. Continuous distress in an oncology clinic in Turkey: should we make use of the distress thermometer mandatory as a precautionary measure for physicians? J BUON. 2014 Jul-Sep;19(3):807-11.

Sedef AM, Köse F, Sümbül AT, Doğan Ö, Beşen AA, Tatlı AM, Mertsoylu H, Sezer A, Muallaoğlu S, Özyılkan Ö, Abalı H. Patients with distal intestinal gastric cancer have superior outcome with addition of taxanes to combination chemotherapy, while proximal intestinal and diffuse gastric cancers do not: does biology and location predict chemotherapy benefit? Med Oncol. 2015 Feb;32(2):476. doi: 10.1007/s12032-014-0476-8. Epub 2015 Jan 9.

Sümbül AT, Dişel U, Sezgin N, Sezer A, Köse F, Beşen AA, Sümbül Z, Abalı H, Özyılkan Ö. Can serial monitoring of serum Vascular Endothelial Growth Factor (VEGF), Nitric Oxide (NO), and Angiotensin II (ANGII) levels have predictive role during Bevacizumab treatment? Med Sci Monit. 2014 Mar 15;20:428-33. doi: 10.12659/MSM.889945.

Sadik M, Ozlem K, Huseyin M, AliAyberk B, Ahmet S, Ozgur O. Attributes of cancer patients admitted to the emergency department in one year. World J Emerg Med. 2014;5(2):85-90. doi: 10.5847/wjem.j.issn.1920-8642.2014.02.001.

Sedef AM, Karaduman D, Besen AA, Mertsoylu H, Köse F. Erken evre endometrium kanseri tanılı hastaların tedavi sonuçları: tek merkez deneyimi. Cukurova Medical Journal. 2019. doi:10.17826/cumj.491549.

Sedef AM, Çalıkuşu Z, Bahçeci A, Gökçay S, Besen AA, Sümbül AT. İleri evre küçük hücreli akciğer kanseri olan hastalarda bazal nötrofil lenfosit oranının prognostik değeri. Cukurova Medical Journal. 2018. doi:10.17826/cumj.458042.

Beşen AA. Malignite ilişkili vena kava superior sendromunun tedavisinde stent uygulanmasının etkinliği: tek merkez deneyimi. Ortadoğu Tıp Dergisi. 2018. doi:10.21601/ortadogutipdergisi.457666.

Yıldırım B, Sümbül AT, Topkan E, Özdemir Y, Besen AA, Güler OC, Sedef AM, Önal C. Adjuvant uzatılmış temozolamid tedavisinin glioblastoma multiforme hastalarının sağkalımına etkisi. Cukurova Medical Journal. 2018. doi:10.17826/cumj.335536.

Sedef AM, Köse F, Sümbül AT, Mertsoylu H, Besen AA, Sezer A, Özyılkan Ö, Abalı H. Nöroendokrin tümörlerin klinikohistopatolojik özellikleri ve tedavi sonuçları: tek merkez deneyimi. Cukurova Medical Journal. 2018;43(3):533-538. doi:10.17826/cumj.335741.

Sedef AM, Çalıkuşu Z, Bakkal Temi Y, Gökçay S, Mertsoylu H, Besen AA, Köse F. EGFR mutasyonu veya ALK translokasyonu olan küçük hücreli dışı akciğer kanseri (KHDAK) tanılı hastaların klinik özelliklerinin ve yönetiminin incelenmesi: retrospektif gözlemsel çok merkezli vaka serisi çalışması. Ortadoğu Tıp Dergisi. 2018;10(3):361-367.